Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Sickle cell anemia is associated with unusual clinical heterogeneity for a Mendelian
disorder. Fetal hemoglobin concentration and coincident α thalassemia, both which directly …

Importance The association between sickle cell trait (SCT) and chronic kidney disease
(CKD) is uncertain. Objective To describe the relationship between SCT and CKD and …

Summary Renal failure occurs in 5–18% of sickle cell disease (SCD) patients and is
associated with early mortality. At‐risk SCD patients cannot be identified prior to the …

Early manifestations of sickle nephropathy include glomerular hyperfiltration and proteinuria,
typically microalbuminuria. Over time, a subset of patients develops histologic changes …

Sickle cell disease (SCD) produces many structural and functional abnormalities in the
kidney, including glomerular abnormalities. Albuminuria is the most common manifestation …

Background In patients with diabetes mellitus, hyperfiltration precedes the development of
albuminuria. Pediatric sickle cell anemia (SCA) patients have a high prevalence of …

Results The prevalence of abnormal albuminuria was 20.7%(23.0% in HbSS/HbSβ 0, 16.8%
in HbSC/HbSβ+). Among HbSS/HbSβ 0, abnormal albuminuria was associated with …

To evaluate the association between haemoglobinuria and chronic kidney disease (CKD) in
sickle cell anaemia (SCA), we analysed 356 adult haemoglobin SS or Sβo thalassaemia …