Challenges and opportunities in long COVID research

RE Hamlin, CA Blish - Immunity, 2024 - cell.com
Long COVID (LC) is a condition in which patients do not fully recover from the initial SARS-
CoV-2 infection but rather have persistent or new symptoms for months to years following …

Consequences beyond acute SARS-CoV-2 infection in children

SH Saydah, AP Campbell, AG Randolph - Science Translational …, 2024 - science.org
Although most children are spared from developing complications from SARS-CoV-2
infection, some may suffer consequences including Long Covid and multisystem …

[HTML][HTML] Characteristics and predictors of Long Covid in children: a 3-year prospective cohort study

A Camporesi, R Morello, A La Rocca, G Zampino… - …, 2024 - thelancet.com
Summary Background Children can develop Long Covid, however long term outcomes and
their predictors are poorly described in these patients. The primary aim is to describe …

[HTML][HTML] Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Z Rong, H Mai, G Ebert, S Kapoor, VG Puelles… - Cell Host & Microbe, 2024 - cell.com
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the
underlying mechanisms remain unclear. Using optical clearing and imaging, we observed …

Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescents

Q Wu, B Zhang, J Tong, LC Bailey, HT Bunnell… - …, 2025 - thelancet.com
Background The impact of pre-infection vaccination on the risk of long COVID remains
unclear in the pediatric population. We aim to assess the effectiveness of BNT162b2 on long …

Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

V Calcaterra, S Zanelli, A Foppiani, E Verduci… - Diseases, 2024 - mdpi.com
Long COVID affects both children and adults, including subjects who experienced severe,
mild, or even asymptomatic SARS-CoV-2 infection. We have provided a comprehensive …

[HTML][HTML] mRNA COVID-19 vaccine safety among children and adolescents: a Canadian National Vaccine Safety Network cohort study

P Soe, OG Vanderkooi, M Sadarangani… - The Lancet Regional …, 2024 - thelancet.com
Summary Background The Canadian National Vaccine Safety Network conducted active
safety surveillance for COVID-19 vaccines. This study aimed to characterize the short-to …

COVID-19 in children: Evolving epidemiology, immunology, symptoms, diagnostics, treatment, post covid conditions, prevention strategies, and future directions

J Wurm, N Ritz, P Zimmermann - Journal of Allergy and Clinical …, 2024 - Elsevier
The epidemiology of COVID-19 in children has evolved throughout the pandemic, with
initially low infection rates rising significantly due to the emergence of the more transmissible …

Pediatric SARS-CoV-2 long term outcomes study (PECOS): cross sectional analysis at baseline

GA Montealegre Sanchez, LE Arrigoni, AB Yonts… - Pediatric …, 2024 - nature.com
Background PECOS is an ongoing study aimed to characterize long-term outcomes
following pediatric SARS-CoV-2 infection. Methods This is a cross-sectional analysis of …

[HTML][HTML] Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants …

M Šmíd, T Barusová, J Jarkovský, O Májek… - …, 2024 - eurosurveillance.org
Background COVID-19 remains a major infectious disease with substantial implications for
individual and public health including the risk of a post-infection syndrome, long COVID. The …