Adaptation in protein fitness landscapes is facilitated by indirect paths

NC Wu, L Dai, CA Olson, JO Lloyd-Smith, R Sun - Elife, 2016 - elifesciences.org
The structure of fitness landscapes is critical for understanding adaptive protein evolution.
Previous empirical studies on fitness landscapes were confined to either the neighborhood …

Universality classes of interaction structures for NK fitness landscapes

S Hwang, B Schmiegelt, L Ferretti, J Krug - Journal of Statistical Physics, 2018 - Springer
Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic
fitness landscapes that aim to capture generic features of epistatic interactions in multilocus …

From adaptive dynamics to adaptive walks

A Kraut, A Bovier - Journal of mathematical biology, 2019 - Springer
We consider an asexually reproducing population on a finite type space whose evolution is
driven by exponential birth, death and competition rates, as well as the possibility of …

Accessibility percolation in random fitness landscapes

J Krug - Probabilistic Structures in Evolution, 2021 - ems.press
An evolving population traces out a path in the space of genetic sequences or genotypes.
Depending on the level of resolution, the genotype may be described in terms of nucleotide …

Phase transition for accessibility percolation on hypercubes

L Li - Journal of Theoretical Probability, 2018 - Springer
In this paper, we consider accessibility percolation on hypercubes, ie, we place iid uniform
[0, 1] random variables on vertices of a hypercube, and study whether there is a path …

Accessibility percolation on Cartesian power graphs

B Schmiegelt, J Krug - Journal of Mathematical Biology, 2023 - Springer
A fitness landscape is a mapping from a space of discrete genotypes to the real numbers. A
path in a fitness landscape is a sequence of genotypes connected by single mutational …

First-passage percolation on Cartesian power graphs

A Martinsson - The Annals of Probability, 2018 - JSTOR
We consider first-passage percolation on the class of “high-dimensional” graphs that can be
written as an iterated Cartesian product G□ G□...□ G of some base graph G as the number …

Accessibility Percolation with Crossing Valleys on n-ary Trees

F Duque, A Roldán-Correa, LA Valencia - Journal of Statistical Physics, 2019 - Springer
In this paper, we study a variation of the accessibility percolation model. This work is also
motivated by evolutionary biology and evolutionary computation. Consider a tree whose …

Undirected polymers in random environment: Path properties in the mean field limit

N Kistler, A Schertzer - arXiv preprint arXiv:2012.04076, 2020 - arxiv.org
We consider the problem of undirected polymers (tied at the endpoints) in random
environment, also known as the unoriented first passage percolation on the hypercube, in …

[引用][C] Structure and accessibility of fitness landscapes

B Schmiegelt - 2023 - Universität zu Köln