Osteosarcomas are intricate cellular ecosystems, where heterotypic interactions significantly
influence disease progression and therapeutic outcomes. Despite their importance, a …

Introduction Osteosarcoma is a common type of bone cancer characterized by a poor
prognosis due to its metastatic nature. The tumor microenvironment (TME) plays a critical …

As cells age, they undergo a remarkable global change: In transcriptional drift, hundreds of
genes become overexpressed while hundreds of others become underexpressed. Using …

Identification of cancer subtypes is a critical step for developing precision medicine. Most
cancer subtyping is based on the analysis of RNA sequencing (RNA-seq) data from patient …

Background In recent years, the incidence of patients with colorectal neuroendocrine
neoplasms (CRNENs) has been continuously increasing. When diagnosed, most patients …

Osteosarcoma (OS) is a highly malignant tumor, and chemotherapy resistance is a major
challenge in the treatment of this disease. This study aims to explore the role of the CLTC …