Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …

In the recent years, knowledge about cancer biomarkers has increased tremendously
providing great opportunities for improving the management of cancer patients by …

There is a large increase in lymphoid malignancy in AT patients and a total absence of
myeloid tumors. Penetrance of the tumor phenotype is about 10% to 15% by early …

The Hippo pathway is a central regulator of organ size and tissue homeostasis. Hippo
kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ …

Yes-associated protein (YAP) has been shown to positively regulate p53 family members
and to be negatively regulated by the AKT proto-oncogene product in promoting apoptosis …

The Hippo signaling pathway was originally characterized by genetic studies in Drosophila
to regulate tissue growth and organ size, and the core components of this pathway are …

▪ Abstract Gene mutations provide valuable clues to cellular metabolism. In humans such
insights come mainly from genetic disorders. Ataxia-telangiectasia (AT) and Nijmegen …

Publisher Summary The chapter focuses on the current level of understanding of the roles
both p53 and mutated in ataxia-telangiectasia (ATM) play in cell cycle control in response to …

[Frontiers in Bioscience 17, 331-348, January 1, 2012] 331 WW domain-containing proteins:
Retrospectives and the future Zaidoun Page 1 [Frontiers in Bioscience 17, 331-348, January …