Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to
barrier penetration, tissue dissemination, inflammation, and pathogen transmission. Like cell …

Scrub typhus is an understudied, potentially lethal disease caused by infection with Orientia
tsutsugamushi. Despite causing an estimated 1 million cases per year and an increasing …

Thirty-nine years ago, scrub typhus (ST), a disease, was not among the China's notifiable
diseases. However, ST has reemerged to become a growing public health issue in the …

With the exponential increase in the number of bacterial taxa with genome sequence data, a
new standardized method to assign species designations is needed that is consistent with …

Orientia tsutsugamushi is an obligately intracellular bacterium and the etiological agent of
scrub typhus. The lung is a major target organ of infection, displaying type 1-skewed …

Most bacteria divide through a highly conserved process called binary fission, in which there
is symmetric growth of daughter cells and the synthesis of peptidoglycan at the mid-cell to …

Introduction: Scrub typhus is a mite-borne infection widespread in Southeast Asia, with
clinical symptoms such as fever, chills, skin rash, eschar at the bite site, and other signs of …

Ubiquitin mediated signaling contributes critically to host cell defenses during pathogen
infection. Many pathogens manipulate the ubiquitin system to evade these defenses. Here …

Background Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute
febrile illness in children in the rural tropics. Methods We recruited 60 febrile pediatric …

Scrub typhus is an under diagnosed re-emerging vector borne disease caused by an
intracellular gram negative bacteria, Orientia. The disease is commonly prevalent in rural …