Protein misfolding and related human diseases: A comprehensive review of toxicity, proteins involved, and current therapeutic strategies
AN Khan, RH Khan - International Journal of Biological Macromolecules, 2022 - Elsevier
Most of the cell's chemical reactions and structural components are facilitated by proteins.
But proteins are highly dynamic molecules, where numerous modifications or changes in the …
But proteins are highly dynamic molecules, where numerous modifications or changes in the …
[HTML][HTML] Recent advances in natural products targeting α-synuclein aggregation or clearance in Parkinson's disease
Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of
misfolded α-synuclein fibrils, leading to the formation of Lewy bodies. Currently, no effective …
misfolded α-synuclein fibrils, leading to the formation of Lewy bodies. Currently, no effective …
A natural small molecule‐mediated inhibition of alpha‐synuclein aggregation leads to neuroprotection in Caenorhabditis elegans
T Srivastava, D Tyagi, S Fatima… - Journal of …, 2023 - Wiley Online Library
Small molecules are being explored intensively for their applications as therapeutic
molecules in the management of metabolic and neurological disorders. The natural small …
molecules in the management of metabolic and neurological disorders. The natural small …
[HTML][HTML] A pipeline for natural small molecule inhibitors of endoplasmic reticulum stress
D Correia da Silva, P Valentão, PB Andrade… - Frontiers in …, 2022 - frontiersin.org
The homeostasis of eukaryotic cells is inseverable of that of the endoplasmic reticulum (ER).
The main function of this organelle is the synthesis and folding of a significant portion of …
The main function of this organelle is the synthesis and folding of a significant portion of …
A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
M Subramani, A Sivaperuman, R Natarajan… - Medicinal …, 2023 - ingentaconnect.com
Dementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-
synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most …
synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most …
Cysteine Pathogenic Variants of PMM2 Are Sensitive to Environmental Stress with Loss of Structural Stability
F Yu, L Lin, J Sun, J Pan, Y Liao, Y Pan… - Oxidative Medicine …, 2023 - Wiley Online Library
Congenital disorders of glycosylation (CDG) are severe metabolic disorders caused by an
imbalance in the glycosylation pathway. Phosphomannomutase2 (PMM2‐CDG), the most …
imbalance in the glycosylation pathway. Phosphomannomutase2 (PMM2‐CDG), the most …
[PDF][PDF] Protein misfolding and medicinal strategies in neurodegenerative disorders
L Mehboudi, M Zahedirad, P Vadiei - Academic Journal of Health …, 2022 - ibdigital.uib.es
Proteins that misfold may accumulate and cause disorders like Alzheimer's and Parkinson's.
New medicines are also explored to forecast and even cure these illnesses' severe …
New medicines are also explored to forecast and even cure these illnesses' severe …
Ethnopharmacology and Neurodegenerative Disorders
TC Mohammadi, G Farzanegan… - Journal of Applied …, 2023 - journals.fmsbi.com
Neurodegenerative disorders, exemplified by Alzheimer's and Parkinson's diseases,
significantly affect both individuals and healthcare systems. Despite continuous research …
significantly affect both individuals and healthcare systems. Despite continuous research …