S Murrell, SC Wu, M Butler - Biotechnology advances, 2011 - Elsevier
Dengue viral infection has become an increasing global health concern with over two-fifths of the world's population at risk of infection. It is the most rapidly spreading vector borne …
BAG Coller, DE Clements, AJ Bett, SL Sagar… - Vaccine, 2011 - Elsevier
Challenges associated with the interference observed between the dengue virus components within early tetravalent live-attenuated vaccines led many groups to explore the …
TM Ross - Clinics in laboratory medicine, 2010 - labmed.theclinics.com
Dengue fever (DF), the most prevalent arthropod-borne viral illness in humans, is caused by the dengue virus (DENV). The 4 serotypes of DENV (DENV 1-4) are transmitted to humans …
MG Guzman, L Hermida, L Bernardo… - Expert review of …, 2010 - Taylor & Francis
A dengue vaccine should induce long-lasting, simultaneous protection to the four dengue viruses while avoiding the immune enhancement of viral infection. Domain III of the dengue …
L Hermida, L Bernardo, J Martín, M Alvarez, I Prado… - Vaccine, 2006 - Elsevier
We have previously reported the construction and evaluation in mice of recombinant fusion proteins formed by a fragment (aa 286–426) of the dengue envelope protein and the P64k …
LE Yauch, S Shresta - Advances in virus research, 2014 - Elsevier
Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and subtropical regions, causing hundreds of millions of infections each year. Infections range …
AP Durbin, SS Whitehead - Dengue Virus, 2010 - Springer
Each of the DENV serotypes can cause the full spectrum of dengue illness. Epidemiological studies have implicated preexisting heterotypic DENV antibody as a risk factor for more …
There is currently no vaccine to prevent dengue (DEN) virus infection, which is caused by any one of four closely related serotypes, DEN-1, DEN-2, DEN-3, or DEN-4. A DEN vaccine …
S Brandler, C Ruffie, V Najburg, MP Frenkiel… - Vaccine, 2010 - Elsevier
Dengue disease is an increasing global health problem that threatens one-third of the world's population. To control this emerging arbovirus, an efficient preventive vaccine is still …