Dengue fever: causes, complications, and vaccine strategies

N Khetarpal, I Khanna - Journal of immunology research, 2016 - Wiley Online Library
Dengue is a highly endemic infectious disease of the tropical countries and is rapidly
becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is …

Review of dengue virus and the development of a vaccine

S Murrell, SC Wu, M Butler - Biotechnology advances, 2011 - Elsevier
Dengue viral infection has become an increasing global health concern with over two-fifths
of the world's population at risk of infection. It is the most rapidly spreading vector borne …

The development of recombinant subunit envelope-based vaccines to protect against dengue virus induced disease

BAG Coller, DE Clements, AJ Bett, SL Sagar… - Vaccine, 2011 - Elsevier
Challenges associated with the interference observed between the dengue virus
components within early tetravalent live-attenuated vaccines led many groups to explore the …

Dengue virus

TM Ross - Clinics in laboratory medicine, 2010 - labmed.theclinics.com
Dengue fever (DF), the most prevalent arthropod-borne viral illness in humans, is caused by
the dengue virus (DENV). The 4 serotypes of DENV (DENV 1-4) are transmitted to humans …

Domain III of the envelope protein as a dengue vaccine target

MG Guzman, L Hermida, L Bernardo… - Expert review of …, 2010 - Taylor & Francis
A dengue vaccine should induce long-lasting, simultaneous protection to the four dengue
viruses while avoiding the immune enhancement of viral infection. Domain III of the dengue …

A recombinant fusion protein containing the domain III of the dengue-2 envelope protein is immunogenic and protective in nonhuman primates

L Hermida, L Bernardo, J Martín, M Alvarez, I Prado… - Vaccine, 2006 - Elsevier
We have previously reported the construction and evaluation in mice of recombinant fusion
proteins formed by a fragment (aa 286–426) of the dengue envelope protein and the P64k …

Dengue virus vaccine development

LE Yauch, S Shresta - Advances in virus research, 2014 - Elsevier
Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and
subtropical regions, causing hundreds of millions of infections each year. Infections range …

Dengue vaccine candidates in development

AP Durbin, SS Whitehead - Dengue Virus, 2010 - Springer
Each of the DENV serotypes can cause the full spectrum of dengue illness. Epidemiological
studies have implicated preexisting heterotypic DENV antibody as a risk factor for more …

[PDF][PDF] An envelope domain III-based chimeric antigen produced in Pichia pastoris elicits neutralizing antibodies against all four dengue virus serotypes

B Etemad, G Batra, R Raut, S Dahiya, S Khanam… - Am J Trop Med …, 2008 - Citeseer
There is currently no vaccine to prevent dengue (DEN) virus infection, which is caused by
any one of four closely related serotypes, DEN-1, DEN-2, DEN-3, or DEN-4. A DEN vaccine …

Pediatric measles vaccine expressing a dengue tetravalent antigen elicits neutralizing antibodies against all four dengue viruses

S Brandler, C Ruffie, V Najburg, MP Frenkiel… - Vaccine, 2010 - Elsevier
Dengue disease is an increasing global health problem that threatens one-third of the
world's population. To control this emerging arbovirus, an efficient preventive vaccine is still …