Catalysts' evolution in the asymmetric conjugate addition of nitroalkanes to electron-poor alkenes

R Ballini, A Palmieri, M Petrini - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
The conjugate addition of nitroalkanes to electron-poor alkenes is a widely used process
which only in the late nineties of the last century has efficiently evolved in its asymmetric …

Cell‐penetrating peptide foldamers: drug‐delivery tools

M Oba - ChemBioChem, 2019 - Wiley Online Library
Highly efficient drug‐delivery tools for membrane‐impermeable compounds, proteins, and
nucleic acids in living cells are useful in the fields of chemical biology and drug discovery …

Diversity of secondary structure in catalytic peptides with β-turn-biased sequences

AJ Metrano, NC Abascal, BQ Mercado… - Journal of the …, 2017 - ACS Publications
X-ray crystallography has been applied to the structural analysis of a series of tetrapeptides
that were previously assessed for catalytic activity in an atroposelective bromination …

Reactivity and selectivity of iminium organocatalysis improved by a protein host

AR Nödling, K Świderek, R Castillo, JW Hall… - Angewandte …, 2018 - Wiley Online Library
There has been growing interest in performing organocatalysis within a supramolecular
system as a means of controlling reaction reactivity and stereoselectivity. Here, a protein is …

Isothiourea-catalysed enantioselective Michael addition of N-heterocyclic pronucleophiles to α, β-unsaturated aryl esters

C Shu, H Liu, AMZ Slawin, C Carpenter-Warren… - Chemical …, 2020 - pubs.rsc.org
The isothiourea-catalysed enantioselective Michael addition of 3-aryloxindole and 4-
substituted-dihydropyrazol-3-one pronucleophiles to α, β-unsaturated p-nitrophenyl esters is …

Conjugated enynones: Preparation, properties and applications in organic synthesis

AA Golovanov, IS Odin, SS Zlotskii - Russian Chemical Reviews, 2019 - iopscience.iop.org
Published data on the preparation methods, properties and chemical transformations of
linear-and cross-conjugated enynones are integrated. The molecular and crystal structures …

Catalyst‐Enabled Site‐Divergent Stereoselective Michael Reactions: Overriding Intrinsic Reactivity of Enynyl Carbonyl Acceptors

D Uraguchi, R Shibazaki, N Tanaka… - Angewandte Chemie …, 2018 - Wiley Online Library
A site‐divergent stereoselective Michael reaction system is developed based on the
identification of two distinct catalysts. Cinchonidine‐derived thiourea catalyzes the 1, 4 …

Catalytic foldamers: When the structure guides the function

B Legrand, J Aguesseau-Kondrotas, M Simon… - Catalysts, 2020 - mdpi.com
Enzymes are predominantly proteins able to effectively and selectively catalyze highly
complex biochemical reactions in mild reaction conditions. Nevertheless, they are limited to …

Enhanced and prolonged cell-penetrating abilities of arginine-rich peptides by introducing cyclic α, α-disubstituted α-amino acids with stapling

M Oba, M Kunitake, T Kato, A Ueda… - Bioconjugate …, 2017 - ACS Publications
Cell-penetrating peptides are receiving increasing attention as drug delivery tools, and the
search for peptides with high cell-penetrating ability and negligible cytotoxicity has become …

Recent Progress in the Synthesis of Drugs and Bioactive Molecules Incorporating Nitro (het) arene Core

M Bastrakov, A Starosotnikov - Pharmaceuticals, 2022 - mdpi.com
Aromatic nitro compounds play a unique role in the synthesis of drugs and pharmaceutically
oriented molecules. This field of organic chemistry continues to be in demand and relevant …