Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide
coverage of the metabolome is challenging because of the broad range of physicochemical …

The later that a molecule or molecular class is lost from the drug development pipeline, the
higher the financial cost. Minimizing attrition is therefore one of the most important aims of a …

In the post-genomic era, several profiling tools have been developed to provide a more
comprehensive picture of tumour development and progression. The global analysis of …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

To perform metabonomics investigations, it is necessary to generate comprehensive
metabolite profiles for complex samples such as biofluids and tissue/tissue extracts …

Metabolic profiling, metabolomic and metabonomic studies require robust study protocols for
any large-scale comparisons and evaluations. Detailed methods for solution-state NMR …

Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical
medicine while also providing better understanding of the underlying mechanisms of chronic …

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

In this review, metabonomics, a combination of data-rich analytical chemical measurements
and chemometrics for profiling metabolism in complex systems, is described and its …

The role that metabonomics has in the evaluation of xenobiotic toxicity studies is presented
here together with a brief summary of published studies. To provide a comprehensive …