Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Transposable elements (TEs) are mobile genetic sequences that can jump around the
genome from one location to another, behaving as genomic parasites. TEs have been …

We present the first comprehensive analysis of a diploid human genome that combines
single-molecule sequencing with single-molecule genome maps. Our hybrid assembly …

Interaction of estrogen with iron at the systemic level is long suspected, but direct evidence
linking the two is limited. In the present study, we examined the effects of 17β-estradiol (E2) …

Since their discovery, a growing body of evidence has emerged demonstrating that
transposable elements are important drivers of species diversity. These mobile elements …

DNA methylation primarily occurs on CpG dinucleotides and plays an important role in
transcriptional regulations during tissue development and cell differentiation. Over 25% of …

Dysregulation of cytokines is among the main abnormalities in Systemic Lupus
Erythematosus (SLE). However, although, estrogens, which are known to be involved in …

Oestrogen controls Foxp3 expression in regulatory T cells (Treg cells) via a mechanism
thought to involve oestrogen receptor alpha (ERα), but the molecular basis and functional …

Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack
on the axon-myelin unit. A female MS bias becomes evident after puberty and female …

Endocrine disrupting chemicals (EDCs) such as bisphenol S (BPS) are xenobiotic
compounds that can disrupt endocrine signaling due to steric similarities to endogenous …