Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

Redox homeostasis is maintained by the antioxidant defense system, which is responsible
for eliminating a wide range of oxidants, including reactive oxygen species (ROS), lipid …

Telomeres are essential for genome stability. Oxidative stress caused by excess reactive
oxygen species (ROS) accelerates telomere shortening. Although telomeres are …

Mitochondria are double membrane organelles in eukaryotic cells that provide energy by
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …

This perspective reviews the many dimensions of base excision repair from a 10,000 foot
vantage point and provides one person's view on where the field is headed. Enzyme …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

Genome damage and defective repair are etiologically linked to neurodegeneration.
However, the specific mechanisms involved remain enigmatic. Here, we identify defects in …

Exploring natural plant products as an option to find new chemical entities as anticancer
agents is one of the fastest growing areas of research. Recently, in the last decade, essential …

CNS inflammation is a major driver of MS pathology. Differential immune responses,
including the adaptive and the innate immune system, are observed at various stages of MS …