Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies
Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …
The aging muscle in experimental bed rest: a systematic review and meta-analysis
FG Di Girolamo, N Fiotti, Z Milanović, R Situlin… - Frontiers in …, 2021 - frontiersin.org
Background: Maintaining skeletal muscle mass and function in aging is crucial for
preserving the quality of life and health. An experimental bed rest (BR) protocol is a suitable …
preserving the quality of life and health. An experimental bed rest (BR) protocol is a suitable …
Nutritional strategies to offset disuse-induced skeletal muscle atrophy and anabolic resistance in older adults: from whole-foods to isolated ingredients
Preserving skeletal muscle mass and functional capacity is essential for healthy ageing.
Transient periods of disuse and/or inactivity in combination with sub-optimal dietary intake …
Transient periods of disuse and/or inactivity in combination with sub-optimal dietary intake …
Depressed Protein Synthesis and Anabolic Signaling Potentiate ACL Tear–Resultant Quadriceps Atrophy
Background: Anterior cruciate ligament (ACL) tear (ACLT) leads to protracted quadriceps
muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to …
muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to …
[HTML][HTML] High-dose leucine supplementation does not prevent muscle atrophy or strength loss over 7 days of immobilization in healthy young males
Background Unavoidable periods of disuse lead to muscle atrophy and functional decline.
Preventing such declines can reduce the risk of re-injury and improve recovery of normal …
Preventing such declines can reduce the risk of re-injury and improve recovery of normal …
A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states
Muscle protein synthesis (MPS) and muscle protein breakdown (MPB) are influenced
through dietary protein intake and physical (in) activity, which it follows, regulate skeletal …
through dietary protein intake and physical (in) activity, which it follows, regulate skeletal …
Meals Containing Equivalent Total Protein from Foods Providing Complete, Complementary, or Incomplete Essential Amino Acid Profiles do not Differentially Affect 24 …
EJ Arentson-Lantz, Z Von Ruff, G Connolly… - The Journal of …, 2024 - Elsevier
Background Dietary protein quality can be assessed by skeletal muscle protein synthesis
(MPS) stimulation. Limited knowledge exists on how consuming isonitrogenous meals with …
(MPS) stimulation. Limited knowledge exists on how consuming isonitrogenous meals with …
Dietary protein, exercise, ageing and physical inactivity: interactive influences on skeletal muscle proteostasis
Dietary protein is a pre-requisite for the maintenance of skeletal muscle mass; stimulating
increases in muscle protein synthesis (MPS), via essential amino acids (EAA), and …
increases in muscle protein synthesis (MPS), via essential amino acids (EAA), and …
Important concepts in protein nutrition, aging, and skeletal muscle: honoring Dr Douglas Paddon-Jones (1969–2021) by highlighting his research contributions
EJ Arentson-Lantz, DK Layman, HJ Leidy… - The Journal of …, 2023 - Elsevier
This review is a tribute to honor Dr Douglas Paddon-Jones by highlighting his career
research contributions. Dr Paddon-Jones was a leader in recognizing the importance of …
research contributions. Dr Paddon-Jones was a leader in recognizing the importance of …
Leucine augments specific skeletal muscle mitochondrial respiratory pathways during recovery following 7 days of physical inactivity in older adults
EJ Arentson-Lantz, J Mikovic… - Journal of Applied …, 2021 - journals.physiology.org
Leucine supplementation attenuates the loss of skeletal muscle mass and function in older
adults during bed rest. We sought to determine whether leucine could also preserve and/or …
adults during bed rest. We sought to determine whether leucine could also preserve and/or …