This brief review summarizes current evidence regarding lower extremity peripheral artery
disease (PAD) and lower extremity skeletal muscle pathology. Lower extremity ischemia is …

Transforming growth factor-beta (TGF-β) isoforms are cytokines involved in a variety of
cellular processes, including myofiber repair and regulation of connective tissue formation …

Background Peripheral artery disease (PAD), a manifestation of systemic atherosclerosis
that produces blockages in the arteries supplying the legs, affects approximately 5% of …

Background Peripheral artery disease (PAD), which affects an estimated 27 million people
in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to …

Patients with peripheral artery disease (PAD) develop a myopathy in their ischemic lower
extremities, which is characterized by myofiber degeneration, mitochondrial dysfunction and …

Objective: Decreased oxygen supply is generally accepted as the primary cause of muscle
dysfunction in patients with peripheral arterial occlusive disease (PAOD) and intermittent …

Background The improvement of strength and athletic performance during a competitive
season in elite soccer players is a demanding task for the coach. Aims As whole-body …

Patients with type 2 diabetes respond poorly to treatments for peripheral arterial disease
(PAD) and are more likely to present with the most severe manifestation of the disease …

Lower-extremity peripheral arterial disease (PAD) has increased in prevalence, yet
therapeutic development has remained stagnant. Skeletal muscle health and function has …

Background Lower leg ischemia, myopathy, and limb dysfunction are distinguishing features
of peripheral artery disease (PAD). The myopathy of PAD is characterized by myofiber …