PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

Mitogen‐activated protein kinase (MAPK) signaling pathway is activated in a wide spectrum
of human tumors, exhibiting cardinal oncogenic roles and sustained inhibition of this …

Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate …

Background USP11 is an ubiquitin-specific protease that plays an important role in tumor
progression via different mechanisms. However, the expression and prognostic significance …

Background and Aims Bone is the second most frequent site of metastasis for HCC, which
leads to an extremely poor prognosis. HCC bone metastasis is typically osteolytic, involving …

Simple Summary Cancer is one of the main causes of death worldwide and early detection
is crucial for effective treatment. Scientists have therefore focused on the identification of …

The exact pathogenesis of inflammatory bowel disease (IBD), a chronic gastrointestinal
inflammatory disease comprising Crohn's disease and ulcerative colitis, remains unclear …

Background Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer
with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that …

Recent studies have shown that PPP1R14B was highly expressed in tumor tissues and
patients with high expression of PPP1R14B had poor survival rates. However, the function …

Abstract The ITCH/AIP4 ubiquitin E3 ligase was discovered independently by two groups
searching for atrophin-1 interacting proteins and studying the genetics of mouse coat color …