AIM2 inflammasome: A potential therapeutic target in ischemic stroke

R Fu, L Zhao, Y Guo, X Qin, W Xu, X Cheng, Y Zhang… - Clinical …, 2024 - Elsevier
Ischemic stroke (IS) is a significant global public health issue with a high incidence,
disability, and mortality rate. A robust inflammatory cascade with complex and wide-ranging …

Inflammasome pathway in kidney transplantation

S Granata, D La Russa, G Stallone, A Perri… - Frontiers in …, 2023 - frontiersin.org
Kidney transplantation is the best available renal replacement therapy for patients with end-
stage kidney disease and is associated with better quality of life and patient survival …

Mitophagy, Inflammasomes and Their Interaction in Kidney Diseases: A Comprehensive Review of Experimental Studies

Y Wang, D Song, L Tang - Journal of Inflammation Research, 2023 - Taylor & Francis
Mitophagy is an important mechanism for mitochondrial quality control by regulating
autophagosome-specific phagocytosis, degradation and clearance of damaged …

Human natural killer cells can activate NLRP1 and NLRP3 inflammasomes and drives pyroptosis

A Astorga-Gamaza, I Muela-Zarzuela… - bioRxiv, 2024 - biorxiv.org
Innate immunity relies on inflammasomes as key components, defending the host against
diverse harmful stimuli by orchestrating the release of pro-inflammatory cytokines and …

Engineering Immune-Compatible Organs: Genetic Modifications in Pigs for Reduced Rejection in Human Recipients

X Lin - Animal Molecular Breeding, 2024 - animalscipublisher.com
The shortage of human organs for transplantation has driven significant advancements in
xenotransplantation, particularly using genetically modified pigs. This study examines the …