Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Despite continuous progress in medicine, sepsis remains the main cause of deaths in the
intensive care unit. Liver failure complicating sepsis/septic shock has a significant impact on …

The current nanomedicines for cancer therapy based on the enhance permeability and
retention (EPR) effect remain insufficient to satisfy the clinical need, and the challenges …

Background & Aims The combination of β-blockers and band ligation is the standard
approach to prevent variceal rebleeding, but bleeding recurs and mortality is high. The lipid …

In the recent years, there have been an increasing number of reports on favourable effects of
statins in patients with advanced chronic liver disease. These include reduction in portal …

In chronic liver diseases, an ongoing hepatocellular injury together with inflammatory
reaction results in activation of hepatic stellate cells (HSCs) and increased deposition of …

Background & Aims Statins have been variably shown to decrease risk and complications of
chronic liver diseases (CLDs). We performed a systematic review and meta-analysis to …

Background & Aims Statins decrease portal pressure in patients with cirrhosis and increase
survival times of patients who have bled from varices. However, statins can be hepatotoxic. It …

Objective In the liver, the transcription factor, Kruppel-like factor 2 (KLF2), is induced early
during progression of cirrhosis to lessen the development of vascular dysfunction; …

Background & Aims Cirrhosis and its clinical consequences can be aggravated by bacterial
infections, ultimately leading to the development of acute on chronic liver failure (ACLF) …