The Bruton tyrosine kinase (BTK) inhibitor ibrutinib is increasingly used in the treatment of
chronic lymphocytic leukemia (CLL). Moreover, very promising results have been reported in …

Abstract Purpose of Review Small-molecule kinase inhibitors (SMKIs) have revolutionized
the management of malignant and autoimmune disorders. Emerging clinical reports point …

Abstract Purpose of Review This review discusses fungal infections associated with licenced
small-molecule protein kinase inhibitors. For each major drug class, the mechanism of …

Disseminated disease following invasive pulmonary aspergillosis (IPA) remains a significant
contributor to mortality amongst patients with hematologic malignancies (HMs). At the …

Bruton tyrosine kinase (BTK) inhibitors have become an important therapy for untreated and
previously treated patients with chronic lymphocytic leukemia (CLL). Despite improved …

Since the broad implementation of ibrutinib therapy, an increasing number of studies have
been reported on invasive fungal infections (IFI) associated with ibrutinib administration. We …

Abstract Background Aspergillosis of Central Nervous System (CNS) is a highly lethal
infection in patients with leukemia and Stem Cell Transplantation (SCT). Methods Case …

A 37-year-old male was admitted with an atypical presentation of central nervous system
(CNS) aspergillosis while on ibrutinib therapy for a CNS relapse of mantle cell lymphoma …

The patient described in this case report was admitted to the San Luigi Hospital in Turin for
confusion, drowsiness, and buccal and eye deviation. An acute neurological disease was …

We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional
risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose …