The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …

Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …

The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

T-cell receptor (TCR) diversity, a prerequisite for immune system recognition of the universe
of foreign antigens, is generated in the first two decades of life in the thymus and then …

Background Real-world evidence on the association between autoimmune inflammatory
rheumatic diseases, therapies related to these diseases, and COVID-19 outcomes are …

The immune systems of post-pubescent males and females differ significantly with profound
consequences to health and disease. In many cases, sex-specific differences in the immune …

RA is known to be associated with an increased risk of serious infection. Even more than 50
years ago, observational studies showed a greater than 2-fold increased risk of serious …

Objective A high frequency of infections complicating rheumatoid arthritis (RA) has been
described in reports of case series. This retrospective longitudinal cohort study was …

The decline of the immune system appears to be an intractable consequence of aging,
leading to increased susceptibility to infections, reduced effectiveness of vaccination and …