Gut microbiota and their metabolites in stroke: a double-edged sword

A Peh, JA O'Donnell, BRS Broughton, FZ Marques - Stroke, 2022 - Am Heart Assoc
Besides damaging the brain, stroke causes systemic changes, including to the
gastrointestinal system. A growing body of evidence supports the role of the gut and its …

Targeting the immune system for ischemic stroke

SR Zhang, TG Phan, CG Sobey - Trends in pharmacological sciences, 2021 - cell.com
Stroke is responsible for almost 6 million deaths and more than 10% of all mortalities each
year, and two-thirds of stroke survivors remain disabled. With treatments for ischemic stroke …

Ageing, metabolism and the intestine

MC Funk, J Zhou, M Boutros - EMBO reports, 2020 - embopress.org
The intestinal epithelium serves as a dynamic barrier to the environment and integrates a
variety of signals, including those from metabolites, commensal microbiota, immune …

Ischemic stroke and intestinal flora: an insight into brain–gut axis

W Hu, X Kong, H Wang, Y Li, Y Luo - European journal of medical research, 2022 - Springer
Stroke is a type of cerebrovascular disease that significantly endangers human health and
lowers quality of life. This understandably places a heavy burden on society and families. In …

Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke

X Xie, L Wang, S Dong, SC Ge… - Neural regeneration …, 2023 - journals.lww.com
Local ischemia often causes a series of inflammatory reactions when both brain immune
cells and the peripheral immune response are activated. In the human body, the gut and …

Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: a translational perspective

E Candelario-Jalil, S Paul - Experimental neurology, 2021 - Elsevier
Ischemic stroke is a highly complex and devastating neurological disease. The sudden loss
of blood flow to a brain region due to an ischemic insult leads to severe damage to that area …

[HTML][HTML] Role of the gut microbiota in stroke pathogenesis and potential therapeutic implications

K Yamashiro, N Kurita, T Urabe, N Hattori - Annals of Nutrition and …, 2021 - karger.com
Background: Major advances have been made in stroke treatment and prevention in the
past decades. However, the burden of stroke remains high. Identification of novel targets …

Brain to periphery in acute ischemic stroke: mechanisms and clinical significance

P Cui, LD McCullough, J Hao - Frontiers in neuroendocrinology, 2021 - Elsevier
The social and public health burdens of ischemic stroke have been increasing worldwide. In
addition to focal brain damage, acute ischemic stroke (AIS) provokes systemic abnormalities …

Translocation and dissemination of gut bacteria after severe traumatic brain injury

W Yang, Q Yuan, Z Li, Z Du, G Wu, J Yu, J Hu - Microorganisms, 2022 - mdpi.com
Enterobacteriaceae are often found in the lungs of patients with severe Traumatic Brain
Injury (sTBI). However, it is unknown whether these bacteria come from the gut microbiota …

Distal consequences of mucosal infections in intestinal and lung inflammation

F Melo-González, J Sepúlveda-Alfaro… - Frontiers in …, 2022 - frontiersin.org
Infectious diseases are one of the leading causes of morbidity and mortality worldwide,
affecting high-risk populations such as children and the elderly. Pathogens usually activate …