Elimination of tissue viral reservoirs is likely the key to generation of an effective HIV cure.
Exciting studies have come out recently that reveal crucial insights into topics ranging from …

Antiretroviral therapy controls HIV replication but does not eliminate the virus from the
infected host. The persistence of a small pool of cells harboring integrated and replication …

High-parameter single-cell phenotyping has enabled in-depth classification and
interrogation of immune cells, but to date has not allowed for glycan characterization. Here …

HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If
ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a …

Successful approaches for eradication or cure of HIV-1 infection are likely to include
immunological mechanisms, but remarkably little is known about how human immune …

Abstract Interleukin (IL)‐1β is a key innate cytokine that is essential for immune activation
and promoting the inflammatory process. However, abnormal elevation in IL‐1β levels has …

The aryl hydrocarbon receptor (AhR) regulates Th17-polarized CD4+ T cell functions, but its
role in HIV-1 replication/outgrowth remains unknown. Genetic (CRISPR-Cas9) and …

CD4+ tissue resident memory T cells (TRMs) are implicated in the formation of persistent
HIV reservoirs that are established during the very early stages of infection. The tissue …

Much attention has been paid to a newly discovered subset of memory T (TM) cells—stem
cell-like memory T (T SCM) cells for their high self-renewal ability, multi-differentiation …

Virologic suppression with antiretroviral therapy (ART) has significantly improved health
outcomes for people living with HIV, yet challenges related to chronic inflammation in the …