Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which
functions as an ion channel and a phospholipid scramblase. Despite the availability of …

Activation of Ca 2+-dependent TMEM16 scramblases induces the externalization of
phosphatidylserine, a key molecule in multiple signaling processes. Current models suggest …

Infection by bacteria leads to tissue damage and inflammation, which need to be tightly
controlled by host mechanisms to avoid deleterious consequences. It is previously reported …

Phospholipid scramblases mediate the rapid movement of lipids between membrane
leaflets, a key step in establishing and maintaining membrane homeostasis of the …

Biological membranes are complex and dynamic structures with different populations of
lipids on their inner and outer leaflets. The Ca< 2+/>-activated TMEM16 family of membrane …

Proteins, both membrane dwelling and soluble, have the remarkable ability to alter their
shapes when they interact with other molecules. My work has focused on the ability of one …