Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

The heterogeneity of systemic lupus erythematosus (SLE), long recognised by clinicians, is
now challenging the entire lupus community, from geneticists to clinical investigators …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

Idiopathic nephrotic syndrome is the most frequent pediatric glomerular disease, affecting
from 1.15 to 16.9 per 100,000 children per year globally. It is characterized by massive …

Background Despite renin–angiotensin–aldosterone system blockade and
immunosuppressive treatment, focal segmental glomerulosclerosis (FSGS) often progresses …

Background In nephrotic syndrome, protein leaks from the blood into the urine through the
glomeruli, resulting in hypoproteinaemia and generalised oedema. While most children with …

Objectives Lupus nephritis (LN) is a frequent complication of systemic lupus erythematosus
(SLE). Severe (proliferative) forms of LN are treated with induction immunosuppressive …

This article is published as part of a supplement sponsored by Kidney Disease: Improving
Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of …

Abstract Introduction: C3 glomerulopathy (C3G) is an ultrarare, chronic and progressive
nephropathy mediated by dysregulation of the alternative pathway of complement (AP), with …

Importance Lupus nephritis (LN) is typically treated with intravenous cyclophosphamide
(IVCY), which is associated with serious adverse effects. Tacrolimus may be an alternative …