Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …

The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic
development, injury repair and the pathogenesis of human diseases. In vertebrates, low …

The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular
volume homeostasis and blood pressure through complex mechanisms. Apart from the well …

Cellular senescence is associated with renal disease progression, and accelerated tubular
cell senescence promotes the pathogenesis of renal fibrosis. However, the underlying …

Aging is an independent risk factor for CKD, but the molecular mechanisms that link aging
and CKD are not well understood. The antiaging protein Klotho may be an endogenous …

Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western
countries. Notably, it has a rapidly rising prevalence in China. The patients, commonly …

Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the
globe and is one of the main complications in patients with type 1 and 2 diabetes. The …

Diabetic Nephropathy (DN) is believed to be a major microvascular complication of
diabetes. The hallmark of DN includes deposition of Extracellular Matrix (ECM) proteins …

Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2
diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease …