The role of protein arginine methyltransferases in DNA damage response
In response to DNA damage, cells have developed a sophisticated signaling pathway,
consisting of DNA damage sensors, transducers, and effectors, to ensure efficient and …
consisting of DNA damage sensors, transducers, and effectors, to ensure efficient and …
Metabolic regulation of homologous recombination repair by MRE11 lactylation
Lactylation is a lactate-induced post-translational modification best known for its roles in
epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous …
epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous …
Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway
A Belmonte-Fernández, J Herrero-Ruíz… - Cell Death & …, 2023 - nature.com
Cisplatin and other platinum-based anticancer agents are among the most widely used
chemotherapy drugs in the treatment of different types of cancer. However, it is common to …
chemotherapy drugs in the treatment of different types of cancer. However, it is common to …
Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin
T Zhang, H Yang, Z Zhou, Y Bai, J Wang… - Nature …, 2022 - nature.com
DNA end resection is delicately regulated through various types of post-translational
modifications to initiate homologous recombination, but the involvement of SUMOylation in …
modifications to initiate homologous recombination, but the involvement of SUMOylation in …
Double‐strand DNA break repair: molecular mechanisms and therapeutic targets
J Tan, X Sun, H Zhao, H Guan, S Gao, PK Zhou - MedComm, 2023 - Wiley Online Library
Abstract Double‐strand break (DSB), a significant DNA damage brought on by ionizing
radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death. The …
radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death. The …
[HTML][HTML] The Neglected Sibling: NLRP2 Inflammasome in the Nervous System
L Ducza, B Gaál - Aging and disease, 2024 - ncbi.nlm.nih.gov
While classical NOD-like receptor pyrin domain containing protein 1 (NLRP1) and NLRP3
inflammasomal proteins have been extensively investigated, the contribution of NLRP2 is …
inflammasomal proteins have been extensively investigated, the contribution of NLRP2 is …
Hdac inhibitor sodium butyrate attenuates the DNA repair in transformed but not in normal fibroblasts
OO Gnedina, AV Morshneva, EV Skvortsova… - International journal of …, 2022 - mdpi.com
Many cancer therapy strategies cause DNA damage leading to the death of tumor cells. The
DNA damage response (DDR) modulators are considered as promising candidates for use …
DNA damage response (DDR) modulators are considered as promising candidates for use …
The MRE11 opposes white spot syndrome virus infection through the IRF and Dorsal mediated antiviral pathways in shrimp
P Zhu, X Yan, X Jiang, H Li, R Chen, S Wang… - Fish & Shellfish …, 2022 - Elsevier
Abstract Meiotic recombination 11 (MRE11), a key component of the MRE11-RAD50-NBS1
(MRN) complex, plays important roles in damaged DNA repair and immune response. In this …
(MRN) complex, plays important roles in damaged DNA repair and immune response. In this …
Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex
B Otahalova, Z Volkova, J Soukupova… - International Journal of …, 2023 - mdpi.com
The MRE11, RAD50, and NBN genes encode for the nuclear MRN protein complex, which
senses the DNA double strand breaks and initiates the DNA repair. The MRN complex also …
senses the DNA double strand breaks and initiates the DNA repair. The MRN complex also …