Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

The microtubule (MT) associated protein tau, which is highly expressed in the axons of
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …

Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …

Microtubules (MTs) are a highly successful target for anticancer therapy. MT-stabilizing
agents (MSAs) bind to MTs, promoting their polymerization, blocking mitosis, and causing …

Microtubule-stabilizing agents (MSAs) have been highly successful in the treatment of
cancer in the past 20 years. To date, three classes of MSAs have entered the clinical trial …

Simple Summary Microtubule-interfering drugs have been used alone or in combination in
the treatment of epithelial ovarian cancer. Over the years and with increasing …

Epothilones are natural compounds isolated from a myxobacterium at the beginning of the
1990s, and showed a remarkable anti-neoplastic activity. They act through the same …

The taccalonolides are highly acetylated steroids that stabilize cellular microtubules and
overcome multiple mechanisms of taxane resistance. Recently, two potent taccalonolides …

Our previous work identified an intermediate binding site for taxanes in the microtubule
nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this …

Dictyostatin (DCT, 1) is a complex, flexible polyketide macrolide that demonstrates potent
microtubule-polymerization activity. Both a solution structure (2a) and a possible binding …