Amyotrophic lateral sclerosis (ALS) is an age-related neurodegenerative disorder that is
believed to have complex genetic and environmental influences in the pathogenesis, but …

Glutamate, first identified in 1866, is the primary excitatory neurotransmitter in the brain.
While it is critically important in many highly regulated cortical functions such as learning …

Oxidative stress damage plays a vital role in cerebral ischemia/reperfusion (I/R)
pathogenesis. The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response …

Our objective was to determine if chronic treatment with the non-competitive AMPA
antagonist talampanel is efficacious and safe in subjects with ALS. A double-blind, placebo …

The neurological functional disabilities caused by cerebral infarction significantly deteriorate
life quality and increase the medical and socio-economic costs. Although some molecular …

AMPA receptors are fast ligand-gated members of glutamate receptors in neuronal and
many types of non-neuronal cells. The heterotetramer complexes are assembled from four …

Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease that results in increasing disability and that is uniformly fatal. Since its approval in …

Developing new treatment strategies for acute ischemic stroke in the last twenty years has
offered some important successes, but also several failures. Most trials of neuroprotective …

A novel natural water-soluble acidic polysaccharide (PWESP-3) was isolated from squash
with a molecular mass of 140.519 kDa, which was composed of arabinose (Ara, 35.30 …

Abstract Ethnopharmacological relevance Sheng-Nao-Kang decoction (SNK), a modified
traditional Chinese medicine (TCM), has been used clinically for the treatment of acute and …