Since its discovery, over 30 years ago, CD5 has been used as a marker to identify T cells,
B1-a cells, and B cell chronic lymphocytic leukemia cells. Throughout the years, many …

Cancer is caused by dysregulation in cellular signaling systems that control cell proliferation,
differentiation and cell death. Protein kinase C (PKC), a family of serine/threonine kinases …

CD5 is a scavenger-like receptor expressed in association with the antigen-specific
receptors on T and B-1a lymphocytes. Recent studies reveal a broader biology for CD5 that …

Chronic lymphocytic leukemia (CLL) is unique among B cell malignancies in that the
malignant clones can be featured either somatically mutated or unmutated IGVH genes. CLL …

The development and the propagation of chronic lymphocytic leukemia (CLL) has been
linked to signaling via the B-cell receptor (BCR). Protein kinase C β (PKCβ) is an essential …

The human cd5 gene has two alternative exons 1: exon 1A (E1A) which encodes the full-
length (FL) CD5 protein and exon 1B (E1B) which encodes a truncated (TR) isoform. The FL …

We herein report an innovative antisense approach based on Peptide Nucleic Acids (PNAs)
to down-modulate CD5 expression levels in chronic lymphocytic leukemia (CLL). Using …

ABSTRACT CD5 was one of the first surface receptors described for mouse and human T
lymphocytes. Since then, it has been found to be highly expressed by regulatory T cells and …

Ca2+ signaling is a key regulator of B lymphocyte cell fate and defects in this signaling
pathway have been reported in numerous diseases such as Chronic lymphocytic leukemia …

The treatment of chronic lymphocytic leukaemia (CLL) has been improved by introduction of
monoclonal antibodies (m A bs) that exert their effect through secondary effector …