Interferons (IFNs) are induced by viruses and are the main regulators of the host antiviral
response. They balance tissue tolerance and immune resistance against viral challenges …

Cells need high-sensitivity detection of non-self molecules in order to fight against
pathogens. These cellular sensors are thus of significant importance to medicinal purposes …

Grass carp is an economically important freshwater fish in China, and haemorrhagic disease
caused by GCRV has seriously restricted its farming scale. To understand the host …

The transcriptomic response of Senegalese sole (Solea senegalensis) triggered by two
betanodaviruses with different virulence to that fish species has been assessed using an …

Abstract Interferon (IFN) regulatory factor 3 (IRF3) is a major regulator contributing to the
host away from viral infection. Here, an IRF3 gene from sea perch (LjIRF3) was identified …

Fish red blood cells (RBCs), are integral in several biologic processes relevant to immunity,
such as pathogen recognition, pathogen binding and clearance, and production of effector …

Highlights•A HMGB2 homologue (SsHMGB2) in black rockfish was identified and
characterized.•Expression of SsHMGB2 occurred in multiple tissues and was upregulated …

Wiskott-Aldrich syndrome (WAS) is a disorder characterized by rare X-linked genetic
immune deficiency with mutations in the Was gene, which is specifically expressed in …

In this study, we sequenced and characterized two homologues of interferon-stimulated
gene ISG15, termed as LcISG15-1 and LcISG15-2, from the large yellow croaker …

In this study, the interferon-stimulated gene 15 (referred to as BsISG15) was sequenced and
characterized in Bostrychus sinensis. BsISG15 encodes a 155-amino-acid protein …