Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of
biological activities, including effects on sphingolipid metabolism, platelet aggregation …

Cholesterol autoxidation 1981–1986 - ScienceDirect Skip to main contentSkip to article
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Bridging the gap between basic scientific advances and the understanding of liver disease—
the extensively revised new edition of the premier text in the field. The latest edition of The …

Despite the well-documented association between gallstones and the metabolic syndrome,,
the mechanistic links between these two disorders remain unknown. Here we show that …

By participating in pathways of cholesterol biosynthesis and elimination, different
cytochrome P450 (P450 or CYP) enzymes play an important role in maintenance of …

Introduction The 27-Hydroxylase Pathway 27-Hydroxylation Conversion of 27-
hydroxysteroid to 27carboxysteroid Peroxisomal Boxidation of coprostanoic acids The …

We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six
human subjects. After bolus intravenous injection of known amounts of [24-14 C] cholic acid …

The plasma concentrations of 3β-hydroxy-5-cholestenoic acid, 3β, 7α-dihydroxy-5-
cholestenoic acid and 7α-hydroxy-3-oxo-4-cholestenoic acid have been compared with that …

The liver plays a central role in the regulation of cholesterol homeostasis. Under normal
conditions, cholesterol input into the body equals output; cholesterol homeostasis is …

Publisher Summary This chapter discusses the mechanism of bile-acid biosynthesis in
mammalian liver. Generally, the most important pathway for the metabolism and excretion of …