Electrophilic aldehyde 4-hydroxy-2-nonenal mediated signaling and mitochondrial dysfunction
Reactive oxygen species (ROS), a by-product of aerobic life, are highly reactive molecules
with unpaired electrons. The excess of ROS leads to oxidative stress, instigating the …
with unpaired electrons. The excess of ROS leads to oxidative stress, instigating the …
[HTML][HTML] Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) results in a complex systemic response that
is critical to the pathophysiology of late complications and has important effects on …
is critical to the pathophysiology of late complications and has important effects on …
Spatiotemporal lipidomics reveals key features of brain lipid dynamic changes after cerebral ischemia and reperfusion therapy
Y Ma, Z Chen, Q He, ZN Guo, Y Yang, F Liu, F Li… - Pharmacological …, 2022 - Elsevier
Reperfusion therapy with recombinant tissue plasminogen activator (rtPA) or mechanical
thrombectomy is the most effective treatment for ischemic stroke. However, a large …
thrombectomy is the most effective treatment for ischemic stroke. However, a large …
Transplantation of Roxadustat‐preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic …
J Chen, X Lin, C Yao, LA Bingwa… - CNS Neuroscience …, 2022 - Wiley Online Library
Aims The therapeutic effect of bone marrow stromal cell (BMSC) transplantation for ischemic
stroke is limited by its low survival rate. The purpose of this study was to evaluate whether …
stroke is limited by its low survival rate. The purpose of this study was to evaluate whether …
COVID-19, blood lipid changes, and thrombosis
Although there is increasing evidence that oxidative stress and inflammation induced by
COVID-19 may contribute to increased risk and severity of thromboses, the underlying …
COVID-19 may contribute to increased risk and severity of thromboses, the underlying …
Endothelial specific deletion of autotaxin improves stroke outcomes
Autotaxin (ATX) is an extracellular secretory enzyme (lysophospholipase D) that catalyzes
the hydrolysis of lysophosphatidyl choline to lysophosphatidic acid (LPA). The ATX–LPA …
the hydrolysis of lysophosphatidyl choline to lysophosphatidic acid (LPA). The ATX–LPA …
The role of autotaxin and LPA signaling in embryonic development, pathophysiology and cancer
C Magkrioti, E Kaffe, V Aidinis - International Journal of Molecular …, 2023 - mdpi.com
Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a
secreted enzyme with lysophospholipase D activity, with its primary function being the …
secreted enzyme with lysophospholipase D activity, with its primary function being the …
Mono-(2-ethylhexyl)-phthalate potentiates methylglyoxal-induced blood–brain barrier damage via mitochondria-derived oxidative stress and bioenergetic perturbation
D Kim, E Oh, H Kim, SM Baek, J Cho, EH Kim… - Food and Chemical …, 2023 - Elsevier
Phthalates in contaminated foods and personal care products are one of the most frequently
exposed chemicals with a public health concern. Phthalate exposure is related to …
exposed chemicals with a public health concern. Phthalate exposure is related to …
Designing dual inhibitors of autotaxin-lpar gpcr axis
S Banerjee, S Lee, DD Norman, GJ Tigyi - Molecules, 2022 - mdpi.com
The ATX-LPA-LPAR1 signaling pathway plays a universal role in stimulating diverse cellular
responses, including cell proliferation, migration, survival, and invasion in almost every cell …
responses, including cell proliferation, migration, survival, and invasion in almost every cell …
The ATX–LPA Axis Regulates Vascular Permeability during Cerebral Ischemic-Reperfusion
Endothelial permeability is a major complication that must be addressed during stroke
treatment. Study of the mechanisms underlying blood–brain barrier (BBB) disruption and …
treatment. Study of the mechanisms underlying blood–brain barrier (BBB) disruption and …