Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

How can vaccines contribute to solving the antimicrobial resistance problem?

M Lipsitch, GR Siber - MBio, 2016 - Am Soc Microbiol
There is a growing appreciation for the role of vaccines in confronting the problem of
antimicrobial resistance (AMR). Vaccines can reduce the prevalence of resistance by …

Comparison of Antibody Repertoires against Staphylococcus aureus in Healthy Individuals and in Acutely Infected Patients

A Dryla, S Prustomersky, D Gelbmann… - Clinical and Vaccine …, 2005 - Am Soc Microbiol
The management of staphylococcal diseases is increasingly difficult with present medical
approaches. Preventive and therapeutic vaccination is considered to be a promising …

Vaccine development for bacterial pathogens: Advances, challenges and prospects

IE Mba, HC Sharndama… - Tropical Medicine & …, 2023 - Wiley Online Library
The advent and use of antimicrobials have played a key role in treating potentially life‐
threatening infectious diseases, improving health, and saving the lives of millions of people …

Towards the immune proteome of Staphylococcus aureus–The anti-S. aureus antibody response

S Holtfreter, J Kolata, BM Bröker - International Journal of Medical …, 2010 - Elsevier
This review provides an overview of the antibody response against Staphylococcus aureus,
which challenges the adaptive immune system with a broad and highly variable antigen …

NERVE: new enhanced reverse vaccinology environment

S Vivona, F Bernante, F Filippini - BMC biotechnology, 2006 - Springer
Background Since a milestone work on Neisseria meningitidis B, Reverse Vaccinology has
strongly enhanced the identification of vaccine candidates by replacing several …

Pulling the brakes on fast and furious multiple drug-resistant (MDR) bacteria

AA Khan, KN Manzoor, A Sultan, M Saeed… - International Journal of …, 2021 - mdpi.com
Life-threatening bacterial infections have been managed by antibiotics for years and have
significantly improved the wellbeing and lifetime of humans. However, bacteria have always …

Staphylococcus aureus antigens and challenges in vaccine development

JR Middleton - Expert review of vaccines, 2008 - Taylor & Francis
Staphylococcus aureus is an important cause of nosocomial and community-acquired
infections in humans and animals, as well as mastitis in dairy cattle. Methicillin-resistant S …

Sono‐Triggered Biomimetically Nanoantibiotics Mediate Precise Sequential Therapy of MRSA‐Induced Lung Infection

L Ding, X Liang, J Ma, X Liu, Y Zhang… - Advanced …, 2024 - Wiley Online Library
Bacterial‐induced lower respiratory tract infections are a growing global health concern,
exacerbated by the inefficacy of conventional antibiotics and delivery methods to effectively …

The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria

I Wuethrich, B W. Pelzer, Y Khodamoradi… - Gut …, 2021 - Taylor & Francis
About 100 years ago, the first antibiotic drug was introduced into health care. Since then,
antibiotics have made an outstanding impact on human medicine. However, our society …