During development and throughout adult life, macrophages derived from hematopoietic
progenitors are seeded throughout the body, initially in the absence of inflammatory and …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

We examine the features, origin, turnover, and gene expression of pancreatic macrophages
under steady state. The data distinguish macrophages within distinct intrapancreatic …

The interaction between the immune system and endocrine cells in the pancreas is crucial
for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) …

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …

Genetic and epigenetic mechanisms may interact and together affect biological processes
and disease development. However, most previous studies have investigated genetic and …

The aim of this study was to test the antimicrobial activity of propolis, bee pollen loads and
beeswax samples collected in the year 2009 from two locations in Slovakia to pathogenic …

Type 1 diabetes mellitus (T1DM) is a complex autoimmune disorder that mainly affects
children and adolescents. The elevated blood glucose level of patients with T1DM results …

Beta cells from nondiabetic mice transfer secretory vesicles to phagocytic cells. The passage
was shown in culture studies where the transfer was probed with CD4 T cells reactive to …

The mortality rates of age-related diseases (ARDs) increase exponentially with age.
Processes described by the exponential growth function typically involve a branching chain …