[HTML][HTML] Pharmaceutical co-crystallization: Regulatory aspects, design, characterization, and applications

AR Thayyil, T Juturu, S Nayak… - Advanced pharmaceutical …, 2020 - ncbi.nlm.nih.gov
Pharmaceutical co-crystals are novel class of pharmaceutical substances, which possess an
apparent probability of advancement of polished physical properties offering stable and …

Co-crystals of non-steroidal anti-inflammatory drugs (NSAIDs): Insight toward formation, methods, and drug enhancement

ALCS Nascimento, RP Fernandes, MD Charpentier… - Particuology, 2021 - Elsevier
Pharmaceutical co-crystals have been explored by many researchers as a strategy to
optimize physicochemical properties of solid-state drugs. Their improvements of solubility …

[HTML][HTML] Isomorphism:molecular similarity to crystal structure similarity'in multicomponent forms of analgesic drugs tolfenamic and mefenamic acid

S Ranjan, R Devarapalli, S Kundu, S Saha, S Deolka… - IUCrJ, 2020 - scripts.iucr.org
The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA)
have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is …

Application of Box–Behnken design for processing of mefenamic acid–paracetamol cocrystals using gas anti-solvent (GAS) process

N Wichianphong, M Charoenchaitrakool - Journal of CO2 Utilization, 2018 - Elsevier
The present work deals with the preparation of drug–drug cocrystals of mefenamic acid
(MEF) with paracetamol (PAR) using gas antisolvent (GAS) process with an aim to improve …

Thermal study, temperature diffraction patterns and evolved gas analysis during pyrolysis and oxidative decomposition of novel ternary complexes of light lanthanides …

M Kosińska-Pezda, L Zapała, U Maciołek… - Journal of Analytical and …, 2021 - Elsevier
New ternary lanthanide complexes with mefenamic acid (Hmef) and phenanthroline with the
stoichiometry Ln 2 (mef) 5 (phen)(OH)· nH 2 O (Ln= La and Ce) and Ln 2 (mef) 4 (phen)(OH) …

Synthesis, characterization and study of some of new mefenamic acid derivatives as cytotoxic agents

IA Mohammed, MM Kareem - Journal of Physics: Conference …, 2020 - iopscience.iop.org
A new system drugs derivative was designed from Mefenamic Acid. These derivatives have
been synthesized by reaction between mefenamic acid and different amino drugs via amide …

Spectroscopic characterization of single co-crystal of mefenamic acid and nicotinamide using supercritical CO2

YA Vaksler, D Benedis, AA Dyshin, RD Oparin… - Journal of Molecular …, 2021 - Elsevier
The present study explores the possibility to synthetize, using supercritical fluid, single
crystal of co-crystal formed by mefenamic acid as active pharmaceutical ingredient and …

New sodium mefenamate–nicotinamide multicomponent crystal development to modulate solubility and dissolution: preparation, structural, and performance study

I Nugrahani, F Fisandra, A Horikawa… - Journal of Pharmaceutical …, 2021 - Elsevier
A cocrystal of mefenamic acid (MA)-nicotinamide (NA) has been reported to increase the
solubility of MA, but it still does not exceed the solubility of sodium mefenamate (SM) …

Solid State Synthesis, Spectroscopic, X-ray and Antibacterial Studies of Zn (II) and Fe (III) Complexes of Pyridine-3-Carboxamide and 2-Hydroxybenzoic Acid

GK Obiyenwa, AC Tella, SO Okwoli, OS Oluwafemi - Chemistry Africa, 2024 - Springer
Mixed-ligand metal complexes are being prepared under solvent-free conditions and this
has formed a vital ongoing research focus. One of the purposes is to overcome antimicrobial …

Sustainable Pharmaceutical Preparation Methods and Solid-state Analysis Supporting Green Pharmacy

I Nugrahani - Current Pharmaceutical Analysis, 2021 - benthamdirect.com
Every" entity" or compound has physical and chemical properties as references for the
synthesis and determination of the entity's structure. Thermodynamically, solid-state is the …