Emerging therapies for hepatocellular carcinoma (HCC)

E Chakraborty, D Sarkar - Cancers, 2022 - mdpi.com
Simple Summary Primary liver cancer, also known as Hepatocellular carcinoma (HCC), is
considered to be a major global health challenge. Due to delays in diagnosis at early …

Reprogramming of hepatic metabolism and microenvironment in nonalcoholic steatohepatitis

L Rui, JD Lin - Annual review of nutrition, 2022 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD), a spectrum of metabolic liver disease associated
with obesity, ranges from relatively benign hepatic steatosis to nonalcoholic steatohepatitis …

Roles of peroxisome proliferator‐activated receptors in hepatocellular carcinoma

Y Zhao, H Tan, X Zhang, J Zhu - Journal of Cellular and …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC), the main pathological type of liver cancer, is linked to risk
factors such as viral hepatitis, alcohol intake and non‐alcoholic fatty liver disease (NAFLD) …

HSPA12A is a novel player in nonalcoholic steatohepatitis via promoting nuclear PKM2-mediated M1 macrophage polarization

Q Kong, N Li, H Cheng, X Zhang, X Cao, T Qi, L Dai… - Diabetes, 2019 - Am Diabetes Assoc
Nonalcoholic steatohepatitis (NASH) is the most prevalent cause of chronic liver disease
worldwide. Macrophage-mediated inflammation plays a critical role in NASH pathogenesis; …

Research progress on intervention effect and mechanism of protocatechuic acid on nonalcoholic fatty liver disease

Y Gao, R Tian, H Liu, H Xue, R Zhang… - Critical Reviews in …, 2022 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) has become a surge burden worldwide due to its
high prevalence, with complicated deterioration symptoms such as liver fibrosis and cancer …

ER stress—induced adipocytes secrete-aldo-keto reductase 1B7—containing exosomes that cause nonalcoholic steatohepatitis in mice

H Gu, K Yang, Z Shen, K Jia, P Liu, M Pan… - Free Radical Biology and …, 2021 - Elsevier
Nonalcoholic steatohepatitis (NASH) is an increasingly prevalent liver disease linked to
obesity and associated complications. Endoplasmic reticulum (ER) stress provokes …

Association of adipose tissue and adipokines with development of obesity-induced liver cancer

Y Rajesh, D Sarkar - International Journal of Molecular Sciences, 2021 - mdpi.com
Obesity is rapidly dispersing all around the world and is closely associated with a high risk of
metabolic diseases such as insulin resistance, dyslipidemia, and nonalcoholic fatty liver …

HCC-Related lncRNAs: roles and mechanisms

M Shah, D Sarkar - International journal of molecular sciences, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) presents a significant global health threat, particularly in
regions endemic to hepatitis B and C viruses, and because of the ongoing pandemic of …

MTDH antisense oligonucleotides reshape the immunosuppressive tumor microenvironment to sensitize Hepatocellular Carcinoma to immune checkpoint blockade …

JL Wan, B Wang, ML Wu, J Li, RM Gong, LN Song… - Cancer Letters, 2022 - Elsevier
Immune checkpoint blockade (ICB) therapy is an important treatment option for individuals
with cancer, but it has certain limitations. Identifying a better target that can overcome tumor …

Sirtuin 3‐mediated deacetylation of acyl‐CoA synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver disease

R Sun, X Kang, Y Zhao, Z Wang… - British journal of …, 2020 - Wiley Online Library
Background and Purpose Hepatic fatty acid metabolism disorder, a key pathogenic
mechanism underlying non‐alcoholic fatty liver disease (NAFLD), is associated with the …