Aim To provide a contemporary analysis of incidence trends of infective endocarditis (IE)
with its changing epidemiology over the past two decades in Europe. Methods A systematic …

Background Effective antimicrobial treatment is key for survival in bloodstream infection
(BSI), but the impact of timing of treatment remains unclear. Our aim was to assess the …

Conventional randomized controlled trials (RCTs) can be expensive, time intensive, and
complex to conduct. Trial recruitment, participation, and data collection can burden …

Objective To define the incidence and risk factors for infective endocarditis (IE) following
surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) …

Objective Antibiotic prophylaxis has been recommended for patients at increased risk of
infective endocarditis (IE) undergoing specific invasive procedures (IPs) despite a lack of …

BACKGROUND Infective endocarditis is a heart infection with a first-year mortality rate of≈
30%. It has long been thought that infective endocarditis is causally associated with …

Background Infective endocarditis is an uncommon but serious infection, where evidence for
giving antibiotic prophylaxis before invasive dental procedures is inconclusive. In England …

Background International Classification of Diseases (ICD) code–based claims databases
are often used to study infective endocarditis (IE). However, the quality of ICD coding can …

Background The objective of this paper was to examine temporal changes of infective
endocarditis (IE) incidence and epidemiology in North America. Methods A systematic …

Real world evidence is now accepted by authorities charged with assessing the benefits and
harms of new therapies. Clinical trials based on real world evidence are much less …