Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Simple Summary Glutaminase GLS2 is an enzyme that metabolizes glutamine, one of the
main sources of energy and building blocks in tumor cells. In some types of cancer, this …

Background Mitochondria play central roles in metabolic diseases including nonalcoholic
steatohepatitis (NASH). However, how mitochondria regulate NASH progression remains …

Cuproptosis is a novel form of cell death, correlated with the tricarboxylic acid (TCA) cycle.
However, the metabolic features and the benefit of immune checkpoint inhibitor (ICI) therapy …

Metabolic reprogram is crucial to support cancer cell growth and movement as well as
determine cell fate. Mitochondrial protein acetylation regulates mitochondrial metabolism …

Background Sorafenib resistance is becoming increasingly common and disadvantageous
for hepatocellular carcinoma (HCC) treatment. Ferroptosis is an iron dependent …

Curcumin possesses a wide spectrum of liver cancer inhibition effects, yet it has chemical
instability and poor metabolic properties as a drug candidate. To alleviate these problems, a …

Metastatic cancer is a major cause of cancer-related mortality; however, the complex
regulation process remains to be further elucidated. A large amount of preliminary …

Metabolic reprogramming contributes to the progression and prognosis of various kidney
diseases. Glutamine is the most abundant free amino acid in the body and participates in …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and
its pathophysiological mechanisms remain unknown. IRSp53 family members, such as …