The role of structure and biophysical properties in the pleiotropic effects of statins
Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are
amongst the most prescribed medications worldwide. Most statins work as a competitive …
amongst the most prescribed medications worldwide. Most statins work as a competitive …
Antifungal natural products
Highlights•Natural products play a crucial role in antifungal drug discovery.•Natural products
represent many first-in-class antifungal agents in clinical trials with new modes of …
represent many first-in-class antifungal agents in clinical trials with new modes of …
Drug repurposing strategies in the development of potential antifungal agents
Q Zhang, F Liu, M Zeng, Y Mao, Z Song - Applied Microbiology and …, 2021 - Springer
The morbidity and mortality caused by invasive fungal infections are increasing across the
globe due to developments in transplant surgery, the use of immunosuppressive agents …
globe due to developments in transplant surgery, the use of immunosuppressive agents …
Cinnamaldehyde incorporated gellan/PVA electrospun nanofibers for eradicating Candida biofilm
Immunocompromised patients encounter fungal infections more frequently than healthy
individuals. Conventional drugs associated health risk and resistance, portrayed fungal …
individuals. Conventional drugs associated health risk and resistance, portrayed fungal …
Antifungal effects of statins
Fungal infections are estimated to be responsible for 1.5 million deaths annually. Global anti-
microbial resistance is also observed for fungal pathogens, and scientists are looking for …
microbial resistance is also observed for fungal pathogens, and scientists are looking for …
Atorvastatin liposomes in a 3D-printed polymer film: a repurposing approach for local treatment of oral candidiasis
Oral candidiasis (OC) is an opportunistic fungal infection, common amongst the elderly and
the immunocompromised. Unfortunately, the therapeutic efficacy of common antifungals is …
the immunocompromised. Unfortunately, the therapeutic efficacy of common antifungals is …
The potential of drug repositioning as a short-term strategy for the control and treatment of COVID-19 (SARS-CoV-2): a systematic review
The novel human coronavirus (SARS-CoV-2), the causative agent of COVID-19, has quickly
become a threat to the public health and economy worldwide. Despite the severity of some …
become a threat to the public health and economy worldwide. Despite the severity of some …
Absence of farnesol salvage in Candida albicans and probably in other fungi
Farnesol salvage, a two-step pathway converting farnesol to farnesyl pyrophosphate (FPP),
occurs in bacteria, plants, and animals. This paper investigates the presence of this pathway …
occurs in bacteria, plants, and animals. This paper investigates the presence of this pathway …
Bilayer mucoadhesive buccal films with prolonged release of ciclopirox olamine for the treatment of oral candidiasis: In vitro development, ex vivo permeation testing …
M Gajdošová, D Vetchý, J Muselík, J Gajdziok… - International journal of …, 2021 - Elsevier
The incidence of fungal infections has increased in recent decades not only in patients with
predisposing and risk factors, but it has also spread up due to the widespread use of broad …
predisposing and risk factors, but it has also spread up due to the widespread use of broad …
In vitro study on the potential fungicidal effects of atorvastatin in combination with some azole drugs against multidrug resistant Candida albicans
DE Mahmoud, AHI Faraag, WM Abu El-Wafa - World Journal of …, 2021 - Springer
The resistance of Candida albicans to azole drugs represents a great global challenge. This
study investigates the potential fungicidal effects of atorvastatin (ATO) combinations with …
study investigates the potential fungicidal effects of atorvastatin (ATO) combinations with …