Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …

A new series of (S)-flurbiprofen derivatives 4a–4p and 5a–5n were synthesized with different
aromatic or aliphatic aldehydes and ketones to produce Schiff's bases and their structures …

In this study, twenty eight novel oxadiazole derivatives (5–32) of the marketed available non-
steroidal anti-inflammatory drug (NSAID),(S)-flurbiprofen (1), were synthesized via I2 …

A novel series of quinazolinone-1, 2, 3-triazole hybrids 10a-p were designed, synthesized,
and evaluated for their in vitro α-glucosidase inhibitory activity leading to efficient anti …

In the present study, 28 acyl hydrazones (4–31) of flurbiprofen were synthesized in good to
excellent yield by reacting different aromatic aldehydes with the commercially available drug …

In this review, we present the potential use of the heterocyclic oxadiazole rings in the design
and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the …

Abstract α-Amylase is a target for type-2 diabetes mellitus treatment. However, small
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …

Discovery of α-glucosidase inhibitors has been actively pursued with the aim to develop
therapeutics for the treatment of type-II diabetes mellitus and the other carbohydrate …

Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat
type 2 diabetes mellitus (T2DM). They may be combined with other medications as an …