The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …

RNA modifications, known as the “epitranscriptome”, represent a key layer of regulation that
influences a wide array of biological processes in mesenchymal stem cells (MSCs). These …

Although over 170 chemical modifications have been identified, their prevalence,
mechanism and function remain largely unknown. To enable integrated analysis of diverse …

Programmable RNA pseudouridylation has emerged as a new type of RNA base editor to
suppress premature termination codons (PTCs) that can lead to truncated and nonfunctional …

methylcytosine (m 5 C) is a prevalent RNA modification crucial for gene expression
regulation. However, accurate and sensitive m 5 C sites identification remains challenging …

While the significance of N6-methyladenosine (m6A) in viral regulation has been extensively
studied, the functions of 5-methylcytosine (m5C) modification in viral biology remain largely …

Conspectus Since the discovery of the first chemically modified RNA nucleotide in 1951,
more than 170 types of chemical modifications have been characterized in RNA so far …

Conspectus RNA molecules are not merely a combination of four bases of A, C, G, and U.
Chemical modifications occur in almost all RNA species and play diverse roles in gene …

High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area
of investigation for decades. Currently, most clinically approved therapeutics are small …

Conspectus The development of various chemical methods has enabled scientists to
decipher the distribution features and biological functions of RNA modifications in the past …