This review discusses the potential of CXCR4 chemokine receptor in the design of
anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer …

Simple Summary Gene therapy is one of the most promising approaches to treating various
inherited and acquired diseases by delivering genetic constructs into the cells and tissues of …

Suicide gene therapy was suggested as a possible strategy for the treatment of uterine
fibroids (UFs), which are the most common benign tumors inwomen of reproductive age. For …

В книге рассматриваются современные взгляды о роли генетических, эндокринных и
иммунологических факторов в патогенезе генитального эндометриоза, обсуждаются …

Uterine leiomyoma is the most common benign tumor of the reproductive system. Current
therapeutic options do not simultaneously meet the requirements of long-term efficiency and …

The application of small interfering RNA (siRNA) for specific gene inhibition is a promising
strategy in gene therapy treatments. The efficient cellular delivery of therapeutic siRNA is a …

Efficient and specific delivery of nucleic acid (NA) therapeutics to tumor cells is extremely
important for cancer gene therapy. Various therapeutic strategies include delivery of DNA …

Abstract Development of gene therapy for endometriosis requires inhibition of
vascularization in endometrial lesions. We have previously developed CXCR4 receptor …

Gene therapy using siRNA molecules is nowadays considered as a promising approach.
For successful therapy, development of a stable and reliable vector for siRNA is crucial. Non …

The major barriers for intracellular DNA transportation by cationic polymers are their toxicity,
poor endosomal escape and inefficient nuclear uptake. Therefore, we designed novel …