Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge

C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
The global coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …

[HTML][HTML] Differences and similarities between innate immune evasion strategies of human coronaviruses

H Hoenigsperger, R Sivarajan, KMJ Sparrer - Current Opinion in …, 2024 - Elsevier
Highlights•Human coronaviruses use distinctand similar strategies to counteract innate
defenses.•Insights from SARS-CoV-2 will inspire research on endemic and epidemic …

Human SARS CoV‐2 spike protein mutations

L Guruprasad - Proteins: Structure, Function, and Bioinformatics, 2021 - Wiley Online Library
The human spike protein sequences from Asia, Africa, Europe, North America, South
America, and Oceania were analyzed by comparing with the reference severe acute …

Global landscape of SARS-CoV-2 mutations and conserved regions

MH Abbasian, M Mahmanzar, K Rahimian… - Journal of Translational …, 2023 - Springer
Background At the end of December 2019, a novel strain of Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) disease (COVID-19) has been identified in Wuhan …

Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

K Huang, Y Zhang, X Hui, Y Zhao, W Gong, T Wang… - …, 2021 - thelancet.com
Background An ideal animal model to study SARS-coronavirus 2 (SARS-CoV-2)
pathogenesis and evaluate therapies and vaccines should reproduce SARS-CoV-2 infection …

Distant residues modulate conformational opening in SARS-CoV-2 spike protein

D Ray, L Le, I Andricioaei - Proceedings of the National …, 2021 - National Acad Sciences
Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) involves the
attachment of the receptor-binding domain (RBD) of its spike proteins to the ACE2 receptors …

Effect of SARS-CoV-2 proteins on vascular permeability

R Rauti, M Shahoha, Y Leichtmann-Bardoogo… - Elife, 2021 - elifesciences.org
Severe acute respiratory syndrome (SARS)-CoV-2 infection leads to severe disease
associated with cytokine storm, vascular dysfunction, coagulation, and progressive lung …

Viral mimicry of interleukin-17A by SARS-CoV-2 ORF8

X Wu, T Xia, WJ Shin, KM Yu, W Jung, A Herrmann… - MBio, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers cytokine-
mediated inflammation, leading to a myriad of clinical presentations in COVID-19. The SARS …

Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity

Y Jia, G Shen, S Nguyen, Y Zhang, KS Huang, HY Ho… - BioRxiv, 2020 - biorxiv.org
Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective
approaches to contain the pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome …

Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

TL Toft-Bertelsen, MG Jeppesen, E Tzortzini… - Communications …, 2021 - nature.com
The dire need for COVID-19 treatments has inspired strategies of repurposing approved
drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical …