Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal
proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The …

The ubiquitin proteasome pathway is responsible for most of the protein degradation in
mammalian cells. Rates of degradation by this pathway have generally been assumed to be …

The proteasome degrades most cellular proteins in a controlled and tightly regulated
manner and thereby controls many processes, including cell cycle, transcription, signalling …

INTRODUCTION Many cellular proteins are polyubiquitinated but cannot be directly
degraded by the proteasome because they are well folded, associated with binding …

Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Proteasomal degradation of ubiquitylated proteins is tightly regulated at multiple levels,–. A
primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the …

Summary The Cdc48 ATPase and its cofactors Ufd1/Npl4 (UN) extract polyubiquitinated
proteins from membranes or macromolecular complexes, but how they perform these …

Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …

The ability of ubiquitin to form up to eight different polyubiquitin chain linkages generates
complexity within the ubiquitin proteasome system, and accounts for the diverse roles of …