The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

Since it was first recognized in bacteria and archaea as a mechanism for innate viral
immunity in the early 2010s, clustered regularly interspaced short palindromic repeats …

The study of model organisms has revolutionized our understanding of the mechanisms
underlying normal development, adult homeostasis, and human disease. Much of what we …

Genome-editing technologies, in particular, CRISPR systems, are widely used for targeted
regulation of gene expression and obtaining modified human and animal cell lines, plants …

The CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR
associated proteins) is a prokaryotic system that enables sequence specific recognition and …

Targeted transcriptional modulation in the central nervous system (CNS) can be achieved by
adeno-associated virus (AAV) delivery of CRISPR activation (CRISPRa) and interference …

The treatment of dominantly inherited retinal diseases requires silencing of the pathogenic
allele. RNA interference to suppress gene expression suffers from wide-spread off-target …

Engineering of clustered regularly interspaced short palindromic repeats (CRISPR) and the
CRISPR-associated protein 9 (Cas9) system has enabled versatile applications of CRISPR …

The application of rapidly growing CRISPR toolboxes and methods has great potential to
transform biomedical research. Here, we provide a snapshot of up-to-date CRISPR …

The CRISPR-based gene editing technology has become more and more powerful in
genome manipulation for agricultural breeding, with numerous improved toolsets springing …