Serine metabolism in health and disease and as a conditionally essential amino acid
M Holeček - Nutrients, 2022 - mdpi.com
L-serine plays an essential role in a broad range of cellular functions including protein
synthesis, neurotransmission, and folate and methionine cycles and synthesis of …
synthesis, neurotransmission, and folate and methionine cycles and synthesis of …
[HTML][HTML] 2, 8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 …
J Moellmann, K Krueger, DWL Wong… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Aim Chronic kidney disease (CKD) is accompanied by increased cardiovascular risk and
heart failure (HF). In rodents, 2, 8-dihydroxyadenine (DHA)-induced nephropathy is a …
heart failure (HF). In rodents, 2, 8-dihydroxyadenine (DHA)-induced nephropathy is a …
Solid lipid nanoparticles cyclodextrin-decorated incorporated into gellan gum-based dry floating in situ delivery systems for controlled release of bioactive compounds …
AD Permana, A Sam, ANF Marzaman, A Rahim… - International Journal of …, 2023 - Elsevier
Safflower (Carthamus tinctorius L.) has been explored as a source of natural antioxidant.
However, quercetin 7-O-beta-D-glucopyranoside and luteolin 7-O-beta-D-glucopyranoside …
However, quercetin 7-O-beta-D-glucopyranoside and luteolin 7-O-beta-D-glucopyranoside …
Effect of l-serine on oxidative stress markers in the kidney of streptozotocin-induced diabetic mice
FE Langroudi, MS Narani, A Kheirollahi, A Vatannejad… - Amino Acids, 2023 - Springer
Oxidative stress is critical in the occurrence and development of diabetes and its related
complications. l-serine has recently been shown to reduce oxidative stress, the incidence of …
complications. l-serine has recently been shown to reduce oxidative stress, the incidence of …
Reno-protective effect of low protein diet supplemented with α-Ketoacid through gut microbiota and fecal metabolism in 5/6 nephrectomized mice
Y Zhu, H He, Y Tang, Y Peng, P Hu, W Sun, P Liu… - Frontiers in …, 2022 - frontiersin.org
Background Low protein supplemented with α-ketoacid diet (LKD) was recommended to be
an essential intervention to delay the progression of chronic kidney disease (CKD) in …
an essential intervention to delay the progression of chronic kidney disease (CKD) in …
Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant …
T Gui, Q Chen, J Li, K Lu, C Li, B Xu, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Introduction: Chronic kidney disease (CKD) can lead to significant elevation of 1-
deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in …
deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in …
The role of NF-kB in the downregulation of organic cation transporter 2 expression and renal cation secretion in kidney disease
C Han, J Zheng, F Wang, Q Lu, Q Chen, A Hu… - Frontiers in …, 2022 - frontiersin.org
Organic cation transporter 2 (OCT2), encoded by the SLC22A2 gene, is the main cation
transporter on the basolateral membrane of proximal tubular cells. OCT2 facilitates the entry …
transporter on the basolateral membrane of proximal tubular cells. OCT2 facilitates the entry …
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
Methods We performed a comprehensive metabolomic analysis in a prospective cohort
study of 5144 multi-ancestral individuals with type 2 diabetes in Singapore, using eGFR …
study of 5144 multi-ancestral individuals with type 2 diabetes in Singapore, using eGFR …
Kaempferitrin inhibits colorectal cancer cells by inducing reactive oxygen species and modulating PI3K/AKT signalling pathway
M Govindarasu, P Abirami, G Rajakumar, MA Ansari… - Process …, 2022 - Elsevier
Colorectal cancer is a life-threatening malignancy of high invasive death worldwide, despite
improvements in conventional chemotherapy. Hence, there is an urgent need for new and …
improvements in conventional chemotherapy. Hence, there is an urgent need for new and …
The Role of 1-Deoxysphingolipids and Polyamines in the Pathogenesis of Placental Syndrome
FY Guleroglu, A Cetin, GP Coskun, M Caliskan… - 2024 - researchsquare.com
Background: Placental syndrome mainly composed of preeclampsia and fetal growth
restriction have an impact on the health of mother and baby dyads. While impaired …
restriction have an impact on the health of mother and baby dyads. While impaired …