[HTML][HTML] Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?
Recent evidence indicates that ionizing radiation can enhance immune responses to
tumors. Advances in radiation delivery techniques allow hypofractionated delivery of …
tumors. Advances in radiation delivery techniques allow hypofractionated delivery of …
[HTML][HTML] Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma
HB Barsoumian, R Ramapriyan, AI Younes… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Despite some successes with checkpoint inhibitors for treating cancer, most
patients remain refractory to treatment, possibly due to the inhibitory nature of the tumor …
patients remain refractory to treatment, possibly due to the inhibitory nature of the tumor …
[HTML][HTML] Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma
Background Neuroblastoma (NB) is a childhood cancer for which new treatment options are
needed. The success of immune checkpoint blockade in the treatment of adult solid tumors …
needed. The success of immune checkpoint blockade in the treatment of adult solid tumors …
[HTML][HTML] Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice
AA Pieper, AL Rakhmilevich… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
Background Current clinical trials are using radiation therapy (RT) to enhance an antitumor
response elicited by high-dose interleukin (IL)-2 therapy or immune checkpoint blockade …
response elicited by high-dose interleukin (IL)-2 therapy or immune checkpoint blockade …
Radiation Augments the Local Anti-Tumor Effect of In Situ Vaccine With CpG-Oligodeoxynucleotides and Anti-OX40 in Immunologically Cold Tumor Models
AA Pieper, LM Zangl, DV Speigelman, AS Feils… - Frontiers in …, 2021 - frontiersin.org
Introduction Combining CpG oligodeoxynucleotides with anti-OX40 agonist antibody (CpG+
OX40) is able to generate an effective in situ vaccine in some tumor models, including the …
OX40) is able to generate an effective in situ vaccine in some tumor models, including the …
In situ therapeutic cancer vaccination with an oncolytic virus expressing membrane-tethered IL-2
W Liu, E Dai, Z Liu, C Ma, ZS Guo, DL Bartlett - Molecular Therapy …, 2020 - cell.com
Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV)
to exert systemic immunologic effects on metastases and improve survival. We have utilized …
to exert systemic immunologic effects on metastases and improve survival. We have utilized …
[HTML][HTML] Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model
CC Baniel, EG Sumiec, JA Hank, AM Bates… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Some patients with cancer treated with anticancer monoclonal antibodies
(mAbs) develop antidrug antibodies (ADAs) that recognize and bind the therapeutic …
(mAbs) develop antidrug antibodies (ADAs) that recognize and bind the therapeutic …
[HTML][HTML] Short-course neoadjuvant in situ vaccination for murine melanoma
TJ Aiken, D Komjathy, M Rodriguez… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Surgical resection remains an important component of multimodality treatment
for most solid tumors. Neoadjuvant immunotherapy has several potential advantages …
for most solid tumors. Neoadjuvant immunotherapy has several potential advantages …
[HTML][HTML] Depth of tumor implantation affects response to in situ vaccination in a syngeneic murine melanoma model
PM Carlson, M Mohan, M Rodriguez… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
An important component of research using animal models is ensuring rigor and
reproducibility. This study was prompted after two experimenters performing virtually …
reproducibility. This study was prompted after two experimenters performing virtually …
[HTML][HTML] Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination
PM Carlson, RB Patel, J Birstler… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background The antitumor effects of external beam radiation therapy (EBRT) are mediated,
in part, by an immune response. We have reported that a single fraction of 12 Gy EBRT …
in part, by an immune response. We have reported that a single fraction of 12 Gy EBRT …