End‐to‐end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation

S Mascia, PL Heider, H Zhang, R Lakerveld… - Angewandte …, 2013 - Wiley Online Library
For the past decade, the pharmaceutical industry has been under pressure to improve
efficiency, as rising costs outpaced the development of new pharmaceuticals.[1] A growing …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilagyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Application of temperature cycling for crystal quality control during crystallization

Z Wu, S Yang, W Wu - CrystEngComm, 2016 - pubs.rsc.org
Characteristics of crystal quality, including crystal size distribution, size, morphology,
polymorphism and chirality, have been established as important indicators of crystalline …

[HTML][HTML] Progress of pharmaceutical continuous crystallization

D Zhang, S Xu, S Du, J Wang, J Gong - Engineering, 2017 - Elsevier
Crystallization is an important unit operation in the pharmaceutical industry. At present, most
pharmaceutical crystallization processes are performed in batches. However, due to product …

Progress and opportunities for utilizing seeding techniques in crystallization processes

F Zhang, B Shan, Y Wang, Z Zhu, ZQ Yu… - … Process Research & …, 2021 - ACS Publications
Seeding is a significant but challenging task for optimizing crystallization process operation,
product quality, and process efficiency. With the development of modern crystallization …

Membrane purification techniques for recovery of succinic acid obtained from fermentation broth during bioconversion of lignocellulosic biomass: Current advances …

OO Sadare, O Ejekwu, MF Moshokoa, MO Jimoh… - Sustainability, 2021 - mdpi.com
Recently, the bioconversion of biomass into biofuels and biocommodities has received
significant attention. Although green technologies for biofuel and biocommodity production …

Overview of secondary nucleation: From fundamentals to application

S Xu, Z Hou, X Chuai, Y Wang - Industrial & Engineering …, 2020 - ACS Publications
Secondary nucleation can bring the crystallization process into a more easily controlled
state, and it is playing an important role in controlling crystal size distribution, polymorphism …

Pharmaceutical cocrystals: a perspective on development and scale-up of solution cocrystallization

A Saha, AA Ahangar, AA Dar, S Thirunahari… - Crystal Growth & …, 2023 - ACS Publications
Pharmaceutical cocrystals represent an emergent class of successful materials designed
based on crystal engineering principles, in which the limitations of the extant drugs are …

Continuous-flow tubular crystallization in slugs spontaneously induced by hydrodynamics

M Jiang, Z Zhu, E Jimenez… - Crystal growth & …, 2014 - ACS Publications
A novel continuous crystallizer design is described with the potential to provide improved
control of crystal properties, improved process reproducibility, and reduced scale-up risk …

Continuous crystallization of proteins in a tubular plug-flow crystallizer

P Neugebauer, JG Khinast - Crystal growth & design, 2015 - ACS Publications
Protein crystals have many important applications in many fields, including pharmaceutics.
Being more stable than other formulations, and having a high degree of purity and …