Three decades of animal studies have reproducibly shown that hypothermia is profoundly
cerebroprotective during or after a central nervous system (CNS) insult. The success of …

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease
(PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders …

Background Lyme neuroborreliosis, caused by the bacterium Borrelia burgdorferi affects
both the central and peripheral nervous systems (CNS, PNS). The CNS manifestations …

Alzheimer's disease (AD) is a neurodegenerative disorder. As the demographic shifting
towards an aging population, AD has emerged as a prominent public health concern. The …

Major depressive disorder is a serious neuropsychiatric disorder with high rates of
recurrence and mortality. Many studies have supported that inflammatory processes play a …

A novel series of ferulic acid derivatives was designed and synthesized on the basis of the
multi-target-directed ligands strategy for the treatment of Alzheimer's disease (AD). In vitro …

Alzheimer's disease (AD) is a complex age-related neurodegenerative disease, associated
with central and peripheral metabolic anomalies, such as impaired glucose utilization and …

Fibroblast growth factor (FGF) 21 is one of the FGF members with special endocrine
properties. In the last twenty years, it has attracted intense research and development for its …

Abstract Fibroblast growth factor21 (FGF21), a member of the FGF family, plays multiple
biological functions including anti-inflammation, anti-oxidative stress, and anti-apoptosis. It …

Microglial polarization and the subsequent neuroinflammatory response were identified as
key contributors to the progress of Parkinson's disease (PD). Researchers have shown that …