Evaluation of cancer therapeutics by utilizing 3D tumor models, before clinical studies, could
be more advantageous than conventional 2D tumor models (monolayer cultures). The 3D …

Master transcription factors interact with DNA to establish cell type identity and to regulate
gene expression in mammalian cells,. The genome-wide map of these transcription factor …

The androgen receptor (AR) plays an essential role in the growth and progression of
prostate cancer (CaP). Ligand-activated AR inside the nucleus binds to the androgen …

Endophytic fungi allied to plants have sparked substantial promise in discovering new
bioactive compounds. In this study, propagation of the endophytic fungus Alternaria …

Background Prostate cancer is a broad-spectrum disease, spanning from indolent to a
highly aggressive lethal malignancy. Prostate cancer cell lines are essential tools to …

Purpose: The MYC oncogene is frequently overexpressed in prostate cancer. Upregulation
of ribosome biogenesis and function is characteristic of MYC-driven tumors. In addition, PIM …

Background Approaches based on expression signatures of prostate cancer (PCa) have
been proposed to predict patient outcomes and response to treatments. The transcription …

Resistance to hormone therapy and disease progression is the major challenge in clinical
management of prostate cancer (PC). Drugs currently used in PC therapy initially show a …

Simple Summary Accumulating studies have highlighted the critical roles of microRNAs in
tumorigenesis and cancer treatment responses. Here, we systematically review the scientific …

Androgen receptor (AR) targeting remains the gold standard treatment for advanced
prostate cancer (PCa); however, treatment resistance remains a major clinical problem. To …