Emerging diversity in lipid–protein interactions

V Corradi, BI Sejdiu, H Mesa-Galloso… - Chemical …, 2019 - ACS Publications
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

JI Mobbs, MJ Belousoff, KG Harikumar, SJ Piper… - PLoS …, 2021 - journals.plos.org
G protein–coupled receptors (GPCRs) are critical regulators of cellular function acting via
heterotrimeric G proteins as their primary transducers with individual GPCRs capable of …

Membrane cholesterol access into a G-protein-coupled receptor

R Guixà-González, JL Albasanz… - Nature …, 2017 - nature.com
Cholesterol is a key component of cell membranes with a proven modulatory role on the
function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal …

[HTML][HTML] Lipid interaction sites on channels, transporters and receptors: recent insights from molecular dynamics simulations

G Hedger, MSP Sansom - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
Lipid molecules are able to selectively interact with specific sites on integral membrane
proteins, and modulate their structure and function. Identification and characterization of …

Role of cholesterol in the function and organization of G-protein coupled receptors

TJ Pucadyil, A Chattopadhyay - Progress in lipid research, 2006 - Elsevier
Cholesterol is an essential component of eukaryotic membranes and plays a crucial role in
membrane organization, dynamics and function. The modulatory role of cholesterol in the …

[HTML][HTML] Molecular dynamics simulations of GPCR–cholesterol interaction: An emerging paradigm

D Sengupta, A Chattopadhyay - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
G protein-coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …

Membrane cholesterol in the function and organization of G-protein coupled receptors

YD Paila, A Chattopadhyay - … Transport Proteins: Structure and Function in …, 2010 - Springer
Cholesterol is an essential component of higher eukaryotic membranes and plays a crucial
role in membrane organization, dynamics and function. The G-protein coupled receptors …

Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges

P Sarkar, S Mozumder, A Bej, S Mukherjee… - Biophysical …, 2021 - Springer
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is an intrinsically fluorescent
neurotransmitter found in organisms spanning a wide evolutionary range. Serotonin exerts …

Insights into the relationships between herbicide activities, molecular structure and membrane interaction of cinnamon and citronella essential oils components

L Lins, S Dal Maso, B Foncoux, A Kamili… - International journal of …, 2019 - mdpi.com
Since the 50's, the massive and “environmental naïve” use of synthetic chemistry has
revolutionized the farming community facing the dramatic growth of demography. However …